Sorbinil
- Product Name
- Sorbinil
- CAS No.
- 68367-52-2
- Chemical Name
- Sorbinil
- Synonyms
- CP-45634;(S)-(+)-Sorbinil;Sorbinil >=98% (HPLC);inhibit,Aldose Reductase,Sorbinil,Inhibitor;(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione;(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione;(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione;(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
- CBNumber
- CB81117527
- Molecular Formula
- C11H9FN2O3
- Formula Weight
- 236.2
- MOL File
- 68367-52-2.mol
Sorbinil Property
- Melting point:
- 241-243°
- alpha
- D25 +54.0° (c = 1 in methanol)
- Density
- 1.52
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 8.91±0.20(Predicted)
- color
- white to off-white
- optical activity
- [α]/D +50 to +60°, c = 1 in methanol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S7701
- Product name
- Sorbinil
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- S7701
- Product name
- Sorbinil
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $545
- Updated
- 2024/03/01
- Product number
- CS-0002274
- Product name
- Sorbinil
- Purity
- 98.31%
- Packaging
- 1mg
- Price
- $235
- Updated
- 2021/12/16
Sorbinil Chemical Properties,Usage,Production
Uses
Enzyme inhibitor (aldose reductase).
Uses
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Definition
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.